Testing of recombinant adeno-associated virus-gene loading of dendritic cells for generating potent cytotoxic T lymphocytes against a prototype self-antigen, multiple myeloma HM1.24
نویسندگان
چکیده
From the Departments of Internal Medicine, Gene Therapy Center in Cardiology, and Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock; AR; 2 Department of Microbiology and Immunology, Texas Tech University, Lubbock, TX; Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, the Scientific Direction, Instituto Clinico Humanitas, Rozzano, Milano, Italy, and the Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, P.R. China, 400010.
منابع مشابه
Testing recombinant adeno-associated virus-gene loading of dendritic cells for generating potent cytotoxic T lymphocytes against a prototype self-antigen, multiple myeloma HM1.24.
Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen loading of dendritic cells (DCs) generates significant and rapid (one stimulation per week) cytotoxic T-lymphocyte (CTL) responses in vitro against viral antigens. As a more extensive analysis of the rAAV system, we have used a self-antigen, HM1.24, expressed in multiple myeloma (MM). Again, with one stimula...
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تاریخ انتشار 2003